antibacterial, antifungal and cytotoxic evaluation of some new 2,3-disubstituted 4(3h)-quinazolinone derivatives
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چکیده
in this study antibacterial, antifungal and cytotoxic effects of some new 2,3-disubstituted 4(3h)-quinazolinone derivatives have been evaluated. the in vitro antibacterial and antifungal tests of new synthesized compounds were performed using maba method against six strains of bacteria (three gram-positive and three gram-negative) and three strains of fungi. also minimum bactericidal concentration (mbc) and minimum fungicidal concentration (mfc) tests were performed. all synthesized compounds indicated mild antibacterial effects especially against gram-negative bacteria. the most sensitive bacteriumwas e. coli. all strains of tested fungi were sensitive to the synthesized compounds mostly at 32 μg/ml and there was no significant differences in the sensitivity of the tested compounds. mbc and mfc data indicated that tested compounds act as bactriostatic and fungistatic agents. cytotoxic activity of the compounds was screened at 1, 10 and 100 µm concentrations against hela cells using the mtt colorimetric assay. while the synthesized compounds did not show significant cytotoxic activities, compounds 7a 3 and 7a 4 reduced cell viability to about 50% at 100 µm concentration. the present study revealed that most of the new synthesized compounds possess good antifungal effects and they could be considered as valuable candidates for further structural modification to design more potent antifungal agents.
منابع مشابه
Antibacterial, antifungal and cytotoxic evaluation of some new 2,3-disubstituted 4(3H)-quinazolinone derivatives
In this study antibacterial, antifungal and cytotoxic effects of some new 2,3-disubstituted 4(3H)-quinazolinone derivatives have been evaluated. The in vitro antibacterial and antifungal tests of new synthesized compounds were performed using MABA method against six strains of bacteria (three Grampositive and three Gram-negative) and three strains of fungi. Also Minimum Bactericidal Concentrati...
متن کاملsynthesis and antibacterial, antifungal and cytotoxic evaluation of some new 2,3-disubstituted 4(3h)-quinazolinone derivatives
متن کامل
antibacterial, antifungal and cytotoxic evaluation of some new quinazolinone derivatives
quinazolinone ring system is renown because of its wide spectrum of pharmacological activities due to various substitutions on this ring system. in this study, the minimum inhibitory concentration of the synthesized compounds in our laboratory was determined by micro dilution alamar blue ® assay against six strains of bacteria (three gram-positive and three gram-negative) and three strains of f...
متن کاملSynthesis of some new 2,3-disubstituted-4(3H)quinazolinone derivatives
Quinazolinones are interesting materials because of their valuable biological effects. In this study some new 2,3-disubstituted-4(3H)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. In the last step, a single acylation on the hydrazine moiety afforded final compounds. The structures...
متن کاملsynthesis of some new 2,3-disubstituted-4(3h)quinazolinone derivatives
quinazolinones are interesting materials because of their valuable biological effects. in this study some new 2,3-disubstituted-4(3h)quinqzolinone derivatives were synthesized from anthranilic acid in six steps by introducing a new chiral center to the aliphatic side chain of the quinazolinone. in the last step, a single acylation on the hydrazine moiety afforded final compounds. the structures...
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۳، صفحات ۱۵۱-۰
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